Structural Biology of protein-DNA/RNA macrocomplexes

Our group is interested in studying the molecular architecture of large multisubunit complexes involved in DNA/RNA-associated functions, with special emphasis on the interaction between retrotransposons and host elements. Traditionally considered "junk" regions of the genome, mobile elements have recently emerged as key players in the development and progression of several diseases, including neurological disorders and cancer. In our laboratory, we intend to study the relevance of these elements at the molecular level through biophysical, biochemical and structural biology tools. We use a combinatorial approach including state-of-the-art cryo-electron microscopy (cryo-EM), X-ray crystallography, and functional studies, among others, to understand the molecular determinants of retrotransposon activity and their underlying function as markers of various human pathologies.