Stem cells, neurogenesis and neurodegeneration

The research of our group is focused on studying the cellular, molecular, and genetic mechanisms involved in three fundamental processes: 1) the differentiation and maturation of human neurons and astrocytes obtained from iPSCs derived from healthy subjects; 2) the alterations of these events that could result in neurodevelopmental disorders, and that could also underlie early steps in the etiology of Parkinson¿s disease (PD) and Alzheimer¿s disease (AD); and 3) the neurodegenerative processes in PD and AD, and the search for new mechanisms and molecular targets in iPSC-derived neurons and glia obtained from patients. Since 2007, Carlos Vicario is also a Principal Investigator of the Spanish Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED-CIBER). Dr. Vicario is a member of the Center for Neural Circuit Mapping (CNCM) at the University of California at Irvin (UCI), https://cncm.som.uci.edu/, from 25/10/2023.