REGULATION OF mRNA TRANSLATION IN EUKARYOTES AND ITS IMPLICATIONS FOR ORGANISMAL LIFE

We're researching how eukaryotic systems regulate mRNA translation globally and specifically. We identify new elements in ribosomes and mRNAs, and activities of initiation factors (eIFs) in differential translation during cell proliferation and stress responses. We study the ES6S region in 40S ribosomal subunits, its role in mRNA entry and scanning in various species. Using SARS-CoV-2's nsp1 protein, we explore how base composition in 5' UTR and CDS regions impacts translation and mRNA stability in human cells. We investigate translation reprogramming during stress in yeast and mammals, its impact on adaptation, survival, and aging. We focus on proteostasis processes like protein aggregation and autophagy, and their effect on cell longevity.