METABOLISM AND B CELL FUNCTION

Our research focuses on understanding the immune response's intricacies during infection, particularly the activation of B lymphocytes that produce antibodies and memory cells. We study the metabolic changes in these cells, known as Germinal Centers (GC), during their initiation, progression, and termination. We have discovered the role of mitochondria in GC reactions and how B cell metabolism influences both B and T cells' functions, which we term "metabolic communication." We use advanced techniques to analyze B cell metabolism and aim to identify molecular mediators of this process. This knowledge could have therapeutic implications for lymphomas, autoimmune diseases, and vaccination strategies.