INTRACELLULAR SIGNALLING IN INFLAMMATORY PROCESSES

Our research focuses on understanding the signaling pathways related to chronic inflammatory diseases, particularly the IL-23/IL-17 axis, which plays a key role in conditions like psoriasis, inflammatory bowel diseases, multiple sclerosis, and rheumatoid arthritis. We aim to uncover new mediators of cytokine signaling and develop therapeutic tools to interfere with these pathways. Recent findings have shown how IL-23 influences pathogenic T cell migration and controls protein synthesis and metabolism to induce pathogenic functions. Our lab is also exploring pharmacological manipulation of immune cell metabolic pathways for treating chronic inflammatory diseases and identifying drugs to disrupt pro-inflammatory signaling for autoimmunity management.