IMMUNOREGULATORY MECHANISMS IN THE DEVELOPMENT OF CHAGAS DISEASE: TRANSLATIONAL APPLICATIONS

During 2021 and 2022, our research focused on: (i) further studying the role of the SLAMF1 immune receptor in Trypanosoma cruzi infection and identifying therapeutic target genes; (ii) assessing the prognostic value of the TCFL5 isoform sCha in Chagas disease patients; (iii) investigating cardiac remodeling in T. cruzi infection; (iv) exploring the mitochondrial genome, transcriptome, and proteome of T. cruzi. We also found autoantibodies predicting sudden death risk in Chagas cardiomyopathy and collaborated on TCFL5 studies in spermatogenesis and colorectal cancer with Dr. Manuel Fresno's research group.