Determinants of mitochondrial physiology and intercellular transfer in the nervous system (Mitodynamics).

Our group seeks to unravel the mechanisms that underlie a wide variety of neurological pathologies, in particular neurodegenerative and oncogenic disorders, which have in common an alteration in mitochondrial function. To explore how they occur, we study the interplay between the morphology, ultrastructure and dynamics of these organelles in the regulation of metabolism, respiration, redox status, and neural bioenergetics. We focus our main interest on the coordination of mitochondrial function between cells and tissues, through intercellular transfer of mitochondrial content.