CELLULAR SIGNALING NETWORKS IN CANCER (ONCO-RESECEL)
Our group is interested in finding out how post-translational modifications of proteins contribute both to cell-autonomous transformation and permissive tumour micro-environments in response to hormonal stress or obesity, and its influence on aberrant proliferation, DNA damage response or aberrant migration and angiogenesis processes, using cellular models and mice models of mammary glands development. We are focused on regulatory feedback loops involving the GRK2 kinase and several ligases and acetylases that are rewired in breast tumoral contexts, also finding out additional relevant GRK2 targets and interactors in epithelial and endothelial cells.
Main specialization
Área de investigación:
Disciplina ERC:
- LS - LIFE SCIENCES
- LS4 Physiology, Pathophysiology and Endocrinology
Industrial Leadership:
- 7. Other
- 7.1. Other
Societal Challenges:
- 1. Health, demographic change and wellbeing
- 1.04. Understanding disease