B lymphocyte dynamics

The complexity of the B lymphocyte immune response involves changes in cell behavior, switching from highly motile states to stable cell-to-cell interactions (immune synapse), adjustments of the cell mechanical properties (flexibility, stiffness) and cell polarity (MTOC and organelle distribution). Gene mutations or functional alterations in proteins related with these events are frequent in B lymphocyte-pathologies (immunodeficiency, lymphomas), stressing their relevance for B cell function. Our research focuses on the molecular mechanisms that govern B lymphocyte dynamics, and how their dysfunction leads to or associates with B cell pathologies, in particular with adult B cell lymphomas.