Animal models of Cutaneous Pathologies

Functional analysis of glucocorticoid and mineralocorticoid receptors in skin biology through transgenic approaches. The class Nr3c of the steroid hormone receptors belongs to the nuclear receptor (NR) superfamily and includes the glucocorticoid (GC) receptor (GR), the mineralocorticoid receptor (MR), and the sex steroid receptors for progesterone and androgens. All NR family members are ligand-dependent transcription factors, whose ability to integrate cellular processes explains that these receptors are the most targeted molecules for the treatment of skin diseases in the clinical practice. Our group aims to study the role of GR and MR in skin development and disease through genetically modified mouse models with gain- and loss-of-function (see publications). The analysis includes molecular and cellular approaches to better understand the mechanisms underlying the action of both NRs. We also attempt to identify individual and common transcriptional targets of GR and MR in skin.