Human immunodeficiency virus replication and antiretroviral therapy

Infections caused by human immunodeficiency viruses (HIV) are a global health burden. Despite progress in antiretroviral therapy, HIV still causes significant deaths. Our lab focuses on understanding HIV's genetic machinery and drug resistance mechanisms. We engineer more accurate DNA synthesizing enzymes for biotech tools and study their roles in viral replication. Our research aims to improve therapies and develop new strategies against HIV's resistance and spread, as well as other viruses with related enzymes and replication mechanisms (e.g. hepatitis B virus and herpesviruses).