- Tipo de expresión:
- Doctorado: Propuesta de dirección de tesis doctoral/temática para solicitar ayuda predoctoral ("Hosting Offer o EoI")
- Ámbito:
- Neurobiologia
- Área:
- Vida
- Modalidad:
- Ayudas para contratos predoctorales para la formación de doctores (antiguas FPI)
- Referencia:
- 2025
- Centro o Instituto:
- CENTRO DE BIOLOGIA MOLECULAR SEVERO OCHOA
- Palabras clave:
-
- Autismo, desarrollo neuronal
- Documentos anexos:
- 721607.pdf
- 721608.pdf
PIF2025 - Developmental Predisposition for Synaptopathies - (PID2024-160995NB-I00)
With this proposal, we aim to decipher generalisable
principles behind normal and abnormal cortex
development. We will combine models to explore the
influence of genetic and environmental stressors on the
synaptic proteome and cortex connectivity. Specifically, we
will use two ASD mouse models (Taok2 KO and 16p11.2
microdeletion) as genetic stressors and a mouse model of
Maternal Immune Activation (MIA) as an environmental
stressor to mechanistically decipher their role affecting
the synaptic proteome and the synaptic pathways related
to neuronal connectivity.