Our research is focused in two main research lines: -Understanding cerebellar long-range connectivity that relays cerebellar output to diverse brain areas. We aim to elucidate how the cerebellum influences the development and function of remote brain circuits, with particular interest on the cerebellar modulation of the developing cortical circuits. -Investigating the development and assembly of local cerebellar circuits.

Research interests: Our research focuses on determining cellular- and circuit-based mechanisms by which higher-order brain regions such as the hippocampus and pre-frontal cortex relay cognitive information to the hypothalamus in order to modulate innate motivated behaviors (sociability, aggression, mating). As alterations in higher brain regions contribute to neuropsychiatric diseases associated with disordered social behaviors, insight into both the normal and abnormal functions of these circuits is of critical importance.

We employ high-resolution cryo-electron microscopy (cryo-EM), in combination with functional experiments, to uncover the structure and mechanism of action of macromolecular protein complexes involved in human disease. The goal of our research is to open new therapeutic avenues by understanding the role of these protein complexes in pathogenesis.

We aim to understand the role of membrane mechanics and protein dynamic involve in different cell process, especially, we are focus on immunological synapse, viral infection and ebriogenesis. We use a wide range of systems (in-vitro to embryos) and technics, particularly HS-AFM and Fast-FLIM.

The research activities of the Group focus on elucidating the structural-functional relationship of virulence factors in pathogenic bacteria. Currently, we investigate the mechanism of action of bacterial effectors delivered by the Type 6 Secretion System (T6SS). Nearly a quarter of sequenced Gram-negative bacteria code for the T6SS, which bacteria employ to inject virulence factors into target cells. The T6SS assembles inside the bacteria.

The Group focus the research activities on coloured foods, ingredients and additives. In line with food quality and safety area, the chemical and biochemical basis responsible for the presence and modifications of chlorophyll and carotenoid pigments are studied. A wide range of aspects are covered: the properties and suitability of the raw material, the processing and preservation of food, and the health benefits derived from their consumption.

Our group is interested in understanding the mechanisms at the origin of force generation, coordination and regulation in biological tissues during animal development. Our group use an interdisciplinary approach, combining expertise in Drosophila genetics and molecular biology with high-resolution live imaging, biophysical analysis and modelling, with the aim of building a quantitative description of the mechano-chemical properties of the morphogenetic processes occurring during Drosophila Melanogaster embryogenesis.

Hormonal, metabolic and ecosystemic aspects of source-sink relations in plants. Optimisation againts enviromental stresses.