The organization of the genetic information in the form of chromatin is critical for cell function since the winding of the DNA around nucleosomes stabilizes it, regulates the accessibility and allows the control of transcriptional programs and the maintenance of cellular identity. However, every time the cell divides the chromatin structure is disorganized.

Our research group is interested in studying the molecular mechanisms that lead to the degeneration of the photoreceptors and the retinal pigment epithelium (RPE) in degenerative retinal pathologies that produce blindness, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Based on the basic knowledge obtained from studies on disease mechanisms, we focus on developing new pharmacological treatments and advanced therapies (gene and cell therapy) for these diseases.

Our group brings over 15 years of experience in stem cell research. Currently, our scientific program aims to investigate the dynamic properties of stem cells, including MSCs, to improve their therapeutic potential. In addition, we explore the use of stem cells for the treatment of central nervous system diseases.

Our research is focused in two main research lines: -Understanding cerebellar long-range connectivity that relays cerebellar output to diverse brain areas. We aim to elucidate how the cerebellum influences the development and function of remote brain circuits, with particular interest on the cerebellar modulation of the developing cortical circuits. -Investigating the development and assembly of local cerebellar circuits.