Plant oxylipins are a class of lipid signals involved in regulating plant development and immunity. Recent studies demonstrate the importance of the 9-LOX and alpha-DOX oxylipin pathways in the defence mechanisms activated by Arabidopsis following infection by hemibiotrophic bacteria in which these oxylipin pathways participate in the three layers of defence -pre-invasion, apoplastic and systemic defence- triggered by plants to prevent Pseudomonas syringae pv tomato DC3000 infection.

Our group is devoted to the structural determination of macromolecular complexes, among them molecular chaperones, proteins that assist the folding of other proteins. We use mainly electron microscopy and image processing techniques, but we combine them with biochemical and molecular biology techniques, to structural and functionaly characterise various molecular chaperones, among them CCT, Hsp90, Hsp70, Hs40 and PFD, and cochaperones like PhLP, Hop, Hip and CHIP. Our group is also interested in the use of single-molecule techniques, in particular optical tweezers, in collaboration with the gr

We work in the field of three-dimensional microscopy, both electron and Soft X-rays microscopy, focusing on the development of new image processing methods for Tomorgraphy. A substantial fraction of our work is devoted to Instruct, the European project in Structural Biology within the ESFRI initiative (European Strategic Forum for Research Infrastructures), being its Image Processing Center (I2PC, for Instruct Image Processing Center)

Our group study DNA-protein interactions involved in DNA break repair and maintenance using novel approaches based on Single Molecule (SM) techniques. SM manipulation and imaging techniques offer huge potential to investigate DNA break repair reactions in completely new ways, providing information that is inaccessible to conventional ensemble experiments.

Structural biology of virus fibres

We are interested in the structural and physical principles that govern assembly and stabilization of complex viruses. As a model system we use adenovirus, a challenging specimen of interest both in basic virology and nanobiomedicine, as well as other structurally related viruses. We approach the problem from an interdisciplinary point of view, combining Biophysics, Computational, Structural and Molecular Biology techniques. Sharing expertise and resources is a key pillar in our work.