First in class neuroprotective small molecule for ischemic stroke

Small molecule that stabilizes the retromer complex, showing strong neuroprotective effects in highly excitotoxic conditions and maintaining key…

Oncogenic Signaling and Theraphy Resistance

Our group is interested in studying how cell signalling (e.g. MAPK, AKT) can affect the malignant transformation process. To this end, we have…

Thyroid Hormones and the Central Nervous System

Study of the role of thyroid hormones in the organism, specially in the brain, and the physiopathological conditions arising from disturbances in…

Neuroprotective strategies

Relevance of antioxidant and anti-inflammatory defense in neurodegenerative diseases

Hypoxia and angiogenesis

The fundamental objective of our group is to deepen our understanding of the molecular machinery of the hypoxia response. Specifically, we seek to…

Bioinformatics and computational biology of cancer evolution

Bioinformatics and computational biology: development and implementation of methods for the analysis of high-throughput data, mainly in evolutionary…

Diagnostic and neuroprotective tools for excitotoxicity and brain ischemia

We are interested in the development of diagnostic strategies and neuroprotective drugs applicable to pathologies associated to the overactivation of…

Rare diseases related to autophagy and intracellular trafficking defects

Study of autophagy and its regulation at the molecular and cellular levels. Roles of autophagy in rare diseases.

Molecular mechanisms of mitochondrial physiopathology

Novel targets in neurodegeneration and cancer