Vesicle trafficking, stress response, and morphogenesis in Schizosaccharomyces pombe

Our general objective is to study the role of exocytosis and endocytosis in the regulation of morphogenesis in Schizosaccharomyces pombe. In particular, we are interested in knowing the implication of different vesicle coats and adaptors in this regulation. In addition, mutants lacking some adaptors are sensitive to ionic stress, but not to osmotic or oxidative stress. We are interested in studying the mechanisms involved in this sensitivity. Our initial studies suggest that the exome acts as (or collaborates with) a hub for the coordination of several stress response pathways. At this moment we are studying the role of other adaptors (AP-1, AP-3, GGAs and Epsinas) in the morphogenesis and the stress response of this yeas