Structure of macromolecular targets unit

Research in my laboratory is focused on understanding the molecular mechanisms and cellular functions of proteins and how their defects can lead to disease. We are particularly interested in explaining protein malfunction, in identifying disease-causing variants, and in helping to find new therapeutic strategies to amend the activity of the faulty proteins. My group’s approach relies on a mixture of biochemical and biophysical methods to define the structure, function and evolution of these macromolecular targets. Protein engineering, X-ray crystallography and enzymology form the core of our research approach, but we increasingly combine these methods with single-particle electron microscopy, CRISPR/Cas tools, fluorescence microscopy and cellular assays.