Structure and function of cytoskeleton. Pharmacology and Vaccines.

The pharmacological regulation of the cytoskeleton has been crucial in the development of cancer treatments and currently, it is considered a novel therapeutic target to fight several human diseases, including neurodegenerative diseases and infections. Our challenge is to develop new strategies to fight main human diseases, focusing on finding novel therapeutic targets and drugs candidates within the cell cytoskeleton with improved efficacy and less side effects. Cytoskeleton is one of the main cellular machines due to its implication on cell division, intracellular transport and cell movement, among others. Our group uses an interdisciplinary approach combining cellular biology, biochemistry, biophysics and structural biology techniques to understand at different resolution levels, which are the molecular mechanisms of that control cytoskeleton dynamics and how to regulate them pharmacologically.