Functional organization of the mammalian genome

Our research interests are Genome Biology, DNA replication, transcription and Epigenetics. We focus our investigation in trying to understand how chromatin structure modulates the expression and maintenance of the information encoded in eukaryotic genomes, and how these processes take place within the context of a highly complex and compacted genomic chromatin environment. This knowledge is of fundamental importance to understand the complex role of chromatin in regulating the versatility and stability of our genome both in physiological and pathological conditions. To address this we combine detailed molecular biology approaches with genome-wide approaches and bioinformatics analysis aimed to reveal the complexity of the relationship between transcription and DNA replication.