Cellular and molecular biology of the vascular endothelium

Endoglin is a component of the receptor complex of the TGF-β family in endothelial cells. Mutations in the endoglin gene are responsible for Hereditary Hemorrhagic Telangiectasia type 1 (HHT1). Endoglin regulates angiogenesis and vascular homeostasis, and elevated levels of soluble endoglin have a pathogenic role in preeclampsia. The goal of the laboratory is to study the role of endoglin in vascular pathophysiology.