Antigenic variation and cell signaling in African trypanosomes.

Research in our group focuses on the molecular mechanisms involved in the regulation of gene expression in protozoa parasites of the family Trypanosomatidae. These protozoa are responsible for tropical diseases that affect millions of people in developing countries. In addition, trypanosomes are among the most divergent eukaryotes, so they provide a interesting reference point to identify novel and valuable fundamental biological processes. Among the most interesting biological phenomena described initially in Trypanosoma brucei is the antigenic variation of surface proteins. Antigenic variation is one of the most complex genetic mechanisms have developed a pathogen to evade the host immune system and thus ensure a chronic infection.