PRE2023 - Nanoarchitectonics to create new molecular nanomaterials for biomedical applications (ARMONIA) - PID2022-137332OB-I00

The multidisciplinary project will use nanotechnology and advanced materials as key for the development of new products for health. In this frame, the candidate will use molecular materials and supramolecular chemistry, as a smart strategy to design and control nanostructures for the development of molecular based products, such as nanoparticles, nanovesicles and smart surfaces based of self-assembled monolayers, showing non-conventional chemical, physical and biological properties for advanced therapies, early diagnosis, or disease prevention. High control on nanostructured materials fabrication, deep knowledge of their physico-chemical characteristics and the analysis of how these materials interact with the biological surrounding will be carried out to identify the critical quality attributes of the new biomaterials essential for activity and safety. Specifically, the candidate will use the novel concept of Nanoarchitectonics to create advanced material platforms, in which self-assembly processes are used to arrange nanosize structural units in advanced materials creating reliable nanosystems. As material building blocks, we are going to use single molecules of different nature and nanosystems developed and well-studied by our group: highly stable unilamellar quatsome nanovesicles, radical dendrimers and self-assembly monolayers to biofunctionalized surfaces. The activity and safety of all advanced materials platforms will be validated for specific medical indications.