Morfogénesis y diferenciación del sístema nervioso de vertebrados

Our group investigates the genetic and dynamic events that coordinate the early development of the visual system, using the zebrafish, chick and mouse as experimental models. Driven by unexpected findings, we have also recently expanded our interests to explore specific aspects of mammalian neurodegeneration and neuroinflammation, with a particular interest in Alzheimer’s Disease (AD). Below we explain the specific aims of our research for the next years for which we count with in-house and external national and international collaborations.

On one side, we will continue of our work on visual system development with the aim of pinpointing the cellular and molecular causes of related congenital defects. On the other side, we will follow our current work related to the role of Secreted Frizzled Related Proteins (Sfrp), which we have demonstrated act as negative modulators of ADAM10, a protease critical in AD pathogenesis.

Especialización principal

Área científica:
Disciplina ERC:
  • LS5 Neurosciences and Neural Disorders
Industrial Leadership:
  • 7. Other
  • 7.1. Other
Societal Challenges:
  • 7. Other
  • 7.1. Other