The role of mitochondria associated ER membranes (MAM) in cellular homeostasis


Our laboratory is currently focused on understanding the role of mitochondria-associated ER membranes (MAM) in the overall lipid homeostasis of neurons In particular, we are trying to unveil the mechanism(s) by which perturbations in mitochondria-associated ER membranes (MAM) and lipid signaling underlie synaptic dysfunction and/or neuronal death in various disorders, including Alzheimer's disease and Amyotrophic Lateral Sclerosis We are also specialized in the identification of lipid biomarkers that either segregate with or predict clinical outcomes of neurological disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Down syndrome. To tackle these fundamental questions, we employ multidisciplinary approaches, which range from molecular and cell biology, protein, and lipid biochemistry (including state-of-the-art ‘lipidomics’-based approaches) to mouse genetics

Main specialization

Área de investigación:
Disciplina ERC:
  • LS - LIFE SCIENCES
  • LS1 Molecular and Structural Biology and Biochemistry
Industrial Leadership:
  • 4. Biotechnology
  • 4.2. Biotechnology-based industrial processes
Societal Challenges:
  • 1. Health, demographic change and wellbeing
  • 1.04. Understanding disease