Gene Expression and RNA metabolism Unit

Gene expression (GE) is a coordinated process that comprises different linked steps like transcription, RNA processing, export to the cytoplasm, translation and degradation of mRNAs. Regulation of gene expression is vital to establishing the metabolic activities in every cell in all organisms, and allows their adaptation to both stress and developmental processes. Deficiencies in gene expression lead to a wide spectrum of severe human pathologies. The discovery of novel crosstalks between all stages of GE has opened new ways to understand it in time and space in a cellular context, allowing to establish new hypotheses of how GE works in living eukaryotic cells trough interconnected steps. Thus, it is essential to decipher these events to have a complete picture of GE and its control. Our main objective is to discover novel mechanisms/factors regulating the epigenome that are connected to downstream events like mRNA processing and export and apply this knowledge to human pathologies