Cellular plasticity and neuropathology

The goal of our lab is to understand how brain’s innate immune cells integrate within neural circuits to influence brain function in health and disease. The questions we pursue are grounded in understanding the interplay between brain physiology and the brain’s innate immune system, as a central axis controlling homeostasis and disease. Our ultimate goal is to develop novel approaches for the treatment of chronic neurodegenerative conditions by modulating immunity and neuroinflammation. We combine animal models of neurodegenerative disease and neuroinflammation, samples from patients with the associated pathologies, mouse genetics, transcriptomics and epigenetic analyses at cell population and single-cell levels, and state-of-the-art histological, cellular and molecular biology methods and techniques.