Integrative and Systems Biology

Systems biology and analyses of mutational robustness and the origin of evolutionary novelties. Our research group focuses on the study of the mutational dynamics underlying the origin of evolutionary novelties, and thus, of biological complexity. We follow two main strategies to achieve this objective: a) the devise of models of mutational robustness provided by heat-shock proteins (also known as molecular chaperones), and b) the experimental evolution of microorganisms under laboratory-controlled conditions and regulated genomic background. It is of particular interest to the group the understanding of the role of gene duplication and molecular chaperones in mutational robustness and canalization of genetic variability and evolution. Results derived from our experiments offer biotechnological potential, in particular with regards to the evolution of novel enzymetic activities of industrial interest in the lab.

Main specialization

Scientific Area:
ERC discipline:
  • LS2 Genetics, Genomics, Bioinformatics and Systems Biology
Industrial Leadership:
  • 4. Biotechnology
  • 4.3. Innovative and competitive platform technologies
Societal Challenges:
  • 1. Health, demographic change and wellbeing
  • 1.09. Transferring knowledge to clinical practice and scalable innovation actions